The discipline of anatomy is becoming increasingly complex due to the greater understanding and development of novel surgical approaches. Due to its very nature, this area does not lend itself to the traditional approaches of teaching and learning. With the emergence of cutting-edge digital media, such as Augmented, Virtual, and Mixed Reality (AR/VR/MR), and the reduction in 3D printing costs, learners can see and touch detailed models and structures that are rare to patients in clinical practice, or impossible to discern on cadavers. Such resources, usually lack a concomitant development approach for educational efficacy together with immersive engagement. Existing disjointed approaches incur overheads in development, with numerous iterations required to ensure ‘fitness for practice’. By developing tools in this manner, resources are embedded with a techno-centric rather than an edu-centric approach to curricular design. Thus, teaching becomes cumbersome, with unforeseen nuances impacting efficacy. ENTICE aims to use co-creative methodologies in order to build a solid creation pipeline for medical experiential content bringing together a network of academics, medical educators and industrial content creators. These stakeholders will develop, evaluate and proliferate edu-centric immersive learning resources and tools aiming to support well-defined learning objectives using tangible and intangible resources (AR/VR/MR, 3D printing) that are highly sought after in the fields of anatomy and surgery. The ENTICE design, implementation and evaluation process will explore the effectiveness and efficiency of novel bespoke educational episodes that will be created within the project, utilizing various delivery approaches. This analysis will be distilled into best practices for academic and industry stakeholders, providing an evidence-based approach to the content creation industries for integration of experiential learning tools in medical education.